Ever since she was a little girl, Escha Malier has held two dreams in her heart: to become an Alchemist like her late mother, and to one day explore the mysterious ruins that float in the sky above her home town. Now, after years of study, she's ready to make the first dream come true, working in the R&D branch of her town's Alchemy department. However, while she has all of the knowledge and skills required to meet the job head on, she's not quite as ready for new coworker, Logix "Logy" Fiscario. They seem to be such total opposites, in everything from their attitudes on life to the tools they prefer. Not to mention that he's from the well-populated central region, while she's always lived out on the very edge of what's left of civilization. But as contaminants and pollution threaten the farmlands that keep their people alive, they'll have to work together to seek out the causes and protect their people from the blight and dust that has consumed most of the world. Because sometimes, when one person alone can't save the world, two of them, working in harmony, can.